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DISSEMINATION & Publication

This page highlights how the ESA programme has disseminated its knowledge through presentations, posters, and publications.

DISSEMINATION

Irene and Charlotte gave an interview to CHUV and UNIL about sepsis and their presentation in Brussel (see below). To see, follow this link.

  • The public awareness and knowledge of sepsis is low. In an international survey (Italy, Spain, United Kingdom, France and the United States), only 12 percent of the public had heard of sepsis and few knew it is a leading cause of death. Early diagnosing of sepsis is lifesaving. Poor public awareness leads to prehospital delay increasing the risk of a bad outcome. To increase public awareness, we would like to focus our stand on the definition and recognition of sepsis in a fun and interactive way.

Therefore, two of our fellows are present on the EU Science is wonderful expo! with a stand on sepsis and sepsis research.

They have the following items (in French and Dutch!)

– The big sepsis game, with questions on sepsis and infections).

– Movies on sepsis and research

– Posters on their research (“From mice to clinic: MDSCs as a marker for diagnosis of sepsis”)

– Information posters on sepsis (together with the global sepsis alliance)

– An interactive poster (on tablets) about sepsis and sepsis research.

 

  • A beautiful video was made on sepsis, to which the AMC (amongst which our fellow Harjeet Singh Virk) contributed:

You can watch it here

 

  • Check out our Fantastic group of ESRs on World Sepsis day!!!

Here they are

  • And a video on what sepsis actually is:  Here
  • The “Sepsis Lotgenoten Dag” (A day especially for people who have suffered from Sepsis, so they can share their experiences) is planned the 29th of September 2018! 10.30 -14.00 uur, Velp, The Netherlands.

(click on the icon to go to the website (in Dutch!)

PUBLICATIONS

  1. Chloé Albert Vega, Eleni Karakike, François Bartolo, William Mouton, Elisabeth Cerrato, Karen Brengel-Pesce,Evangelos J. Giamarellos-Bourboulis, François Mallet, Sophie Trouillet-Assant. Differential response induced by LPS and MPLA in immunocompetent and septic individuals. Clinical Immunology, Volume 226, May 2021, 108714. https://doi.org/10.1016/j.clim.2021.108714
  2. Théroude C, Reverte M, Heinonen T, Ciarlo E, Schrijver IT, Antonakos N, Maillard N, Pralong F, Le Roy D, Roger T. Trained Immunity Confers Prolonged Protection From Listeriosis. Front Immunol. 2021 Sep 17;12:723393. doi: 10.3389/fimmu.2021.723393. eCollection 2021.PMID: 34603295
  3. Herderschee J, Heinonen T, Fenwick C, Schrijver IT, Ohmiti K, Moradpour D, Cavassini M, Pantaleo G, Roger T, Calandra T. High-dimensional immune phenotyping of blood cells by mass cytometry in patients infected with hepatitis C virus. Swiss HIV Cohort Study. Clin Microbiol Infect. 2021 Aug 30:S1198-743X(21)00478-X. doi: 10.1016/j.cmi.2021.08.018. Online ahead of print.PMID: 34474121
  4. Ives A, Le Roy D, Théroude C, Bernhagen J, Roger T, Calandra T.Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway.FASEB J. 2021 May;35(5):e21418. doi: 10.1096/fj.202001605R.PMID: 33774873
  5. Fatemeh Asgari, Domenico Supino, Raffaella Parente, Nadia polentarutti, Matteo Stravalaci, Remi Porte, Fabio Pasqualini, Marialuisa Barbagallo, Chiara Perucchini, Camilla Recordati, Elena Magrini, Andrea Mariancini, Federica Riva, Sadaf Davudian, Thierry Roger, Cornelis van’t Veer, Sebastien Jaillon, Alberto Mantovani, Andrea Doni, Cecilia Garlanda. The long pentraxin PTX3 controls Klebsiella pneumoniae severe infection. Front. Immunol., 20 May 2021 | https://doi.org/10.3389/fimmu.2021.666198
  6. Asner SA, Desgranges F, Schrijver IT, Calandra T. Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock. J Infect. 2021 Mar 17:S0163-4453(21)00116-X. doi: 10.1016/j.jinf.2021.03.003. Epub ahead of print. PMID: 33722641.
  7. Chloé Albert-Vega, Guy Oriol, François Bartolo, Jonathan Lopez, Alexandre Pachot, Thomas Rimmelé, FabienneVenet, Véronique Leray, Guillaume Monneret, Benjamin Delwarde, Karen Brengel-Pesce, Julien Textoris, FrançoisMallet and Sophie Trouillet-Assant. Deciphering heterogeneity of Septic Shock Patients using Immune Functional Assays: a proof of concept study. Sci Rep 10, 16136 (2020). https://doi.org/10.1038/s41598-020-73014-2.
  8. Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D. Nat Rev Dis Primers. 2018 Feb 1;4:17107.
  9. The Emerging Role of the Microbiome in the ICU. Nora Suzanne Wolff, Floor Hugenholtz and Willem Joost Wiersinga. Critical Care. 2018;22:78. doi:10.1186/s13054-018-1999-8. doi:  10.1186/s13054-018-1999-8
  10. Ciarlo E, Heinonen T, Théroude C, Herderschee J, Mombelli M, Lugrin J, Pfefferlé M, Tyrrell B, Lensch S, Acha-Orbea H, Le Roy D, Auwerx J, Roger T. Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. Front Immunol. 2017 Aug 28;8: PMID: 28894448.
  11. Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy and Thierry Roger; Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections; Front. Immunol. | doi: 10.3389/fimmu.2018.02675
  12. Chloé Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, François Mallet and Julien Textoris. Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine. Immunol., 16 October 2018. doi.org/10.3389/fimmu.2018.02367
  13. Alban, A., Chick, S. E., and Forster, M. Extending a Bayesian decision-theoretic approach to value-based sequential clinical trial design. (In Proceedings of the 2018 Winter Simulation Conference, 2459-2470, Piscataway, NJ. IEEE, Inc.)
  14. Strouvalis I, Routsi C, Adamopoulou M, Raftogiannis M, Renieris G, Orfanos SE, Kotanidou A, Sabracos L, Giamarellos-Bourboulis EJ. 2018. Early increase of VEGF‐A is associated with resolution of ventilator‐associated pneumonia: Clinical and experimental evidence. Respirology 2018, 23 (10): 942-949.
  15. Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris. Late Peaks of HMGB1 and Sepsis Outcome. Shock. 2018 Sep 19. doi: 10.1097/SHK.0000000000001265.
  16. Karakike, J. Giamarellos-Bourboulis. Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis. Front Immunol. 2019 Jan 31;10:55. doi: 10.3389/fimmu.2019.00055. eCollection 2019
  17. Schrijver IT, Théroude C, Roger T. Myeloid-Derived Suppressor Cells in Sepsis. Front Immunol. 2019 Feb 27;10:327. doi: 10.3389/fimmu.2019.00327. eCollection 2019.
  18. Poulakou G, Renieris G, Sabrakos L, Zarkotou O, Themeli-Digalaki K, Perivolioti E, Kraniotaki E, Giamarellos-Bourboulis EJ, Zavras N. Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumanii with resistance to colistin. Int J Antimicrob Agents. 2019, 53 (2): 190-194.
  19. Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Fatemeh Asgari, Didier Le Roy, Mihai G Netea, Thierry Roger, Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections, The Journal of Infectious Diseases, , jiz692, https://doi.org/10.1093/infdis/jiz692
  20. Karakike, E., Kyriazopoulou, E., Tsangaris, I., Routsi, C., Vincent, J. L., & Giamarellos-Bourboulis, E. J. (2019). The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort. Critical care (London, England), 23(1), 387. https://doi.org/10.1186/s13054-019-2665-5
  21. Goumenos, S., Savvidou, O., Renieris, G., Gkavogianni, T., Papagelopoulos, P. J., & Giamarellos-Bourboulis, E. J. (2020). Staphylococcus Aureus Osteomyelitis as an Inducer of Tolerance to Escherichia Coli Pyelonephritis: an Experimental Study. Scientific reports, 10(1), 1345. https://doi.org/10.1038/s41598-020-58420-w
  22. Porte, R., Davoudian, S., Asgari, F., Parente, R., Mantovani, A., Garlanda, C., & Bottazzi, B. (2019). The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis. Frontiers in immunology, 10, 794. https://doi.org/10.3389/fimmu.2019.00794
  23. Birnie E, Virk HS, Savelkoel J, Spijker R, Bertherat E, Dance DAB, Limmathurotsakul D, Devleesschauwer B, Haagsma JA, Wiersinga WJ. Global burden of melioidosis in 2015: a systematic review and data synthesis. Lancet Infect Dis. 2019 Aug;19(8):892-902. doi: 10.1016/S1473-3099(19)30157-4. Epub 2019 Jul 5.
  24. Bhalodi AA, van Engelen TSR, Virk HS, Wiersinga WJ. Impact of antimicrobial therapy on the gut microbiome. J Antimicrob Chemother. 2019 Jan 1;74(Supplement_1):i6-i15. doi: 10.1093/jac/dky530.
  25. Liassidou A, Renieris G, Droggiti DI, Gkavogianni T, Liassides C, Sabracos L, Giamarellos-Bourboulis EJ, Siristatidis CS. Association of modulation of pro-inflammatory responses by dectin-2 with preterm delivery: An experimental model. Am J Reprod Immunol. 2020 Mar;83(3):e13216. doi: 10.1111/aji.13216. Epub 2020 Jan 2
  26. Towards standardization of immune functional assays. Mouton W, Albert-Vega C, Boccard M, Bartolo F, Oriol G, Lopez J, Pachot A, Textoris J, Mallet F, Brengel-Pesce K, Trouillet-Assant S. Clin Immunol. 2020 Jan;210:108312. doi: 10.1016/j.clim.2019.108312. Epub 2019 Nov 21.
  27. Source of Circulating Pentraxin 3 in Septic Shock Patients. Albert Vega C, Mommert M, Boccard M, Rimmelé T, Venet F, Pachot A, Leray V, Monneret G, Delwarde B, Brengel-Pesce K, Mallet F, Trouillet-Assant S. Front Immunol. 2019 Jan 4;9:3048. doi: 10.3389/fimmu.2018.03048. eCollection 2018.

  28. High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure. Schrijver IT, Karakike E, Théroude C, Baumgartner P, Harari A, Giamarellos-Bourboulis EJ, Calandra T, Roger T. Intensive Care Med Exp. 2022 Feb 11;10(1):5. doi: 10.1186/s40635-022-00431-0.PMID: 35146585

  29. Alban, Andres and Chick, Stephen E. and Foster, Martin, Value-based Clinical Trials: Selecting Recruitment Rates and Trial Lengths in Different Regulatory Contexts (August 31, 2021). INSEAD Working Paper No. 2021/46/TOM, Available at SSRN: https://ssrn.com/abstract=3914670 or http://dx.doi.org/10.2139/ssrn.3914670

  30. Modes of action and diagnostic value of miRNAs in sepsis. Antonakos N, Gilbert C, Théroude C, Schrijver IT, Roger T. Front Immunol. 2022 Aug 5;13:951798. doi: 10.3389/fimmu.2022.951798. eCollection 2022.PMID: 35990654 Free PMC article. Review.

  31. Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial. Karakike E, Scicluna BP, Roumpoutsou M, Mitrou I, Karampela N, Karageorgos A, Psaroulis K, Massa E, Pitsoulis A, Chaloulis P, Pappa E, Schrijver IT, Frantzeskaki F, Lada M, Dauby N, De Bels D, Floros I, Anisoglou S, Antoniadou E, Patrani M, Vlachogianni G, Mouloudi E, Antoniadou A, Grimaldi D, Roger T, Wiersinga WJ, Tsangaris I, Giamarellos-Bourboulis EJ. Crit Care. 2022 Jun 18;26(1):183. doi: 10.1186/s13054-022-04055-4.PMID: 35717241 Free PMC article. Clinical Trial.

  32. COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions. Schrijver IT, Théroude C, Antonakos N, Regina J, Le Roy D, Bart PA, Chiche JD, Perreau M, Pantaleo G, Calandra T, Roger T. Eur J Immunol. 2022 Jun 10:10.1002/eji.202249827. doi: 10.1002/eji.202249827. Online ahead of print.PMID: 35689332 Free PMC article.

  33. High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure. Schrijver IT, Karakike E, Théroude C, Baumgartner P, Harari A, Giamarellos-Bourboulis EJ, Calandra T, Roger T.Intensive Care Med Exp. 2022 Feb 11;10(1):5. doi: 10.1186/s40635-022-00431-0.PMID: 35146585

The publication below was an invited review for the Seminars of Respiratory and Critical Care Medicine Journal 2020:41(1) (The journal chief editor gave glowing feedback, awaiting print):

Harjeet Singh Virk MD, Chiranjay Mukhopadhyay MD, PhD, W.Joost Wiersinga MD, PhD. Meliodosis: a neglected cause of community acquired pneumonia.

Other publications acknowledging ESA-ITN:

Peer-reviewed articles:

  • Rello J, van Engelen TSR, Alp E, Calandra T, Cattoir V, Winfried V. Kern WV, Netea MG, Nseir S, Opal SM, van de Veerdonk FL, Wilcox MH, Wiersinga WJ. Towards precision medicine in sepsis: a position paper of the European Society of Clinical Microbiology and Infectious Diseases. Clinical Microbiology and Infection, 2018 In press
  • New: Research Topic on “The Immunology of Sepsis – Understanding Host Susceptibility, Pathogenesis of Disease, and Avenues for Future Treatment”, edited by Roger T. Frontiers in Immunology. This special theme issue will be dedicated to the European Sepsis Academy (in preparation)
  • Chick SE, M Forster, P Pertile, 2017, A Bayesian Decision-Theoretic Model of Sequential Experimentation with Delayed Responses, Journal Royal Statistical Society Series B, 79(5): 1439—1462, http://onlinelibrary.wiley.com/doi/10.1111/rssb.12225/abstract
  • van der Sluijs AF, ER van Slobbe-Bijlsma, SE Chick, MB Vroom, DA Dongelmans, APJ Vlaar, 2017, The impact of changes in intensive care organization on patient outcome and cost effectiveness – A narrative review, https://dx.doi.org/10.1186/s40560-016-0207-7
  • SE Chick, N Gans, O Yapar, in preparation, Bayesian Sequential Learning for Clinical Trials of Multiple Correlated Technologies, in preparation.

Books and bookchapters:

  • Giesen L, Luuk Giesen MD. What is sepsis? In: Wiersinga WJ, Seymour CW (ed). Handbook of Sepsis. Springer Nature, 2018. DOI https://doi.org/10.1007/978-3-319-73506-1
  • Engelen TSR, Wiersinga WJ, van der Poll T. The pathogenesis of sepsis. In: Wiersinga WJ, Seymour CW (ed). Handbook of Sepsis. Springer Nature, 2018. DOI https://doi.org/10.1007/978-3-319-73506-1
  • Wiersinga WJ, Seymour CW (ed). Handbook of Sepsis. Springer Nature, 200 p, 2018. DOI https://doi.org/10.1007/978-3-319-73506-1
  • Wolff N.S., Hugenholtz F., Wiersinga W.J. (2018) In: Vincent JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2018. Springer, Cham.[dual publication]
  • Tamara Gulic, Rita Silva-Gomes, Sadaf Davoudian, Marina Sironi, Paola Allavena, Alberto Mantovani, Barbara Bottazzi (2020). Tumor-Associated Myeloid Cells in Cancer Progression. In: Rezaei N. (eds) Cancer Immunology. Springer, ChamTumor-Associated Myeloid Cells in Cancer Progression

Presentations

2022

32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Lisbon, April 23-26 2022

  1. Roger T, Ciarlo E, Heinonen T, Théroude C, M. Reverte, C. Gilbert Le Roy D. Trained immunity confers long-term protection from lethal sepsis.
  2. Karakike E, Scicluna BP, Roumpoutsou M, Mitrou I, Karampela N, Karageorgos A, Psaroulis K, Massa E, Pitsoulis A, Chaloulis P, Pappa E, Schrijver IT, Frantzeskaki F, Lada M, Dauby N, De Bels D, Floros I, Anisoglou S, Antoniadou E, Patrani M, Vlachogianni G, Mouloudi E, Antoniadou A, Grimaldi D, Roger T, Wiersinga WJ, Tsangaris I, Giamarellos-Bourboulis EJ. Effect of intravenous clarithromycin on mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome: The INCLASS Randomized Controlled Trial.

6ème Spring Congress of the Swiss Society of General Internal Medicine (SSMIG), SwissTech Convention Center, Lausanne, June 01-03 2022

  1. S Schrijver IT, Karakike E, Gilbert C, Théroude C, Baumgartner P, Harari A, Giamarellos-Bourboulis EJ, Calandra T, Roger T. High levels of monocytic myeloid-derived suppressor cells correlate with improved outcome in sepsis patients with MODS
  2. Schrijver IT, Théroude C, Gilbert C, Antonakos N, Perreau M, Pantaleo G, Calandra T, Roger T. Increase of myeloid-derived suppressor cells and reduced production of cytokines by monocytic and dendritic cells in COVID-19 patients

Joint meeting, International Immunocompromised Host Society (ICHS) 22nd Symposium & Annual Congress Swiss Society for Allergology and Immunology (SSAI), Basel, September 08-11 2022

  1. S Schrijver IT, Karakike E, Gilbert C, Théroude C, Baumgartner P, Harari A, Giamarellos-Bourboulis EJ, Calandra T, Roger T. High levels of monocytic myeloid-derived suppressor cells correlate with improved outcome in sepsis patients with MODS
  2. Schrijver IT, Théroude C, Gilbert C, Antonakos N, Perreau M, Pantaleo G, Calandra T, Roger T. Increase of myeloid-derived suppressor cells and reduced production of cytokines by monocytic and dendritic cells in COVID-19 patients
  3. Gilbert C, Ciarlo E, Heinonen T, Théroude C, M. Reverte, Le Roy D, Roger T. Trained immunity provides durable protection against deadly sepsis

Joint annual meeting 2022 of the Swiss Societies for Infectious Diseases (SSI) and Swiss Society for Hospital Hygiene (SSHH), Interlaken, September 21-33 2022

  1. S Schrijver IT, Karakike E, Gilbert C, Théroude C, Baumgartner P, Harari A, Giamarellos-Bourboulis EJ, Calandra T, Roger T. High levels of monocytic myeloid-derived suppressor cells correlate with improved outcome in sepsis patients with MODS
  2. Schrijver IT, Théroude C, Gilbert C, Antonakos N, Perreau M, Pantaleo G, Calandra T, Roger T. Increase of myeloid-derived suppressor cells and reduced production of cytokines by monocytic and dendritic cells in COVID-19 patients
  3. Gilbert C, Ciarlo E, Heinonen T, Théroude C, M. Reverte, Le Roy D, Roger T. Trained immunity provides durable protection against deadly sepsis

2020-2021

Talks 2020-2021

  • Research Day of the Department of Medicine and the Department of Laboratory Medicine and Pathology, CHUV, Lausanne, February 27 2020. Schrijver IT, Herderschee J, Théroude C, Fenwick C, Baumgartner P, Harari A, Leijte G, Kox M, Pantaleo G, Pickkers P, Calandra T, Roger T. Myeloid-derived suppressor cells (MDSCs) in healthy subjects infused with endotoxin.
  • 31st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Online, July 09-12 2021. Schrijver IT, E. Karakike, C. Théroude, P. Baumgartner, A. Harari, E.J. Giamarellos-Bourboulis, T. Calandra, Roger T. High levels of monocytic myeloid-derived suppressor cells correlate with improved outcome in sepsis patients with MODS
  • 6th European Congress of Immunology, Virtual ECI 2021, September 01-04 2021. Théroude C, Porte R, Bottazzi B, Schrijver IT, Ciarlo E, Le Roy D, Calandra T, Garlanda C, Roger T. Trained immunity increases lung antimicrobial activity of PMNs and protects from pneumococcal pneumonia

2019

  • Fatemeh Asgari “Pentraxin3 plays an important role in defense against Klebsiella pneumoniae infection” congress of the European shock society and congress of the int’l federation of shock (Crete/Greece)
  • Eleni Karakike: « Macrophage activation: A new mechanism of pathogenesis in sepsis » Annual National Training Program in Infectious Diseases 2018-2019 « Hot Topics in Infectious Diseases –Sepsis 2018» Hellenic Society of Infectious Diseases (February 2019, Athens, Greece)
  • Schrijver IT. Diagnostic profiling of MDSCs in sepsis. Congress of Hellenic sepsis study group, 08.06.2018, Marathon, Greece
  • Andres Alban: «Cost-Effective Clinical Trial Design: Application of a Bayesian Sequential Stopping Rule to the ProFHER Pragmatic Trial »  5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton. https://ictmc2019.com/
  • Chloe Albert: «Definition of an immune functional assay to characterized the altered immune status observed in sepsis patients ». Center For Experimental And Molecular Medicine (CEMM)- Amsterdam University Medical Center (June 2019, Amsterdam, The Netherlands)

2018

  • Fatemeh Asgari “The role of PTX3 in severe infection by Klebsiella pneumoniae” (Milan, Italy)
  • Andres Alban: “Extending a Bayesian decision-theoretic approach to value-based sequential clinical trial design” at the 2018 Winter Simulation Conference (December 2018, Gothenburg, Sweden)
  • George Renieris: «Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumanii with resistance to colistin». 21ο Panhellenic Congress of Internal Medicine (October 2018, Athens, Greece).
  • Chloe Albert: «Definition of an immune functional assay to characterized the altered immune status observed in sepsis patients ». Immune Functional Assay course “IFA day” (March 2018, Biomérieux, France)
  • Chloe Albert: Presented her work at the Mérieux Université PhD day (May 2018, Lyon, France)
  • Dina Tawfik: Presented her work at the Mérieux Université PhD day (May 2018, Lyon, France)
  • Chloe Albert: «Definition of an immune functional assay to characterized the altered immune status observed in sepsis patients ». Center For Experimental And Molecular Medicine (CEMM)- Amsterdam University Medical Center (October 2018, Amsterdam, The Netherlands)
  • Dina Tawfik: «Immunoprofiling of ICU patients using FilmArray® Platform». Center For Experimental And Molecular Medicine (CEMM)- Amsterdam University Medical Center (June 2018, Amsterdam, The Netherlands)
  • Dina Tawfik: «Design of a fully integrated molecular tool to manage sepsis patients based on their immune status». Ecole Doctorale Interdisciplinaire Sciences –Sante (EDISS) PhD Day- Claude Bernard University Lyon-1 (October 2018, Lyon, France)

2017

  • Berke Gurkan:“Structure Function of IRAK-M” at the Masterclass Prof Douglas Golenbeck, AMC, The Netherlands
  • Nora Wolff:The difference of murine gut microbiota between different vendors, does it impact infection pathogenesis?” AMC Centre of Molecular Medicine department meeting, AMC, The Netherlands
  • Vera Peters: “Future Research Question in Sepsis” at the ESCMID 2017 postgraduate Sepsis Summer Course. (June 2017, Amsterdam, The Netherlands)
  • Chloe Albert: Presented her work at the Mérieux Université PhD day (May 2017, Lyon, France)
  • Dina Tawfik: Presented her work at the Mérieux Université PhD day (May 2017, Lyon, France)
  • Harjeet Virk: “Future Research Question in Sepsis” at the ESCMID 2017 postgraduate Sepsis Summer Course. (June 2017, Amsterdam, The Netherlands)

All ESRs presented their projects to the ESA-ITN satellite meetings taking place during Sepsis 2017 (13.09.17, Paris).

Posters

2020

Research Day of the Department of Medicine and the Department of Laboratory Medicine and Pathology, CHUV, Lausanne, February 27 2020.

  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Innate lymphoid cells (ILCs) during S. pneumoniae pneumonia.
  • Ciarlo E, Heinonen T, Théroude C, Asgari F, Le Roy D, Netea M, Roger T. Trained immunity confers broad-spectrum protection against bacterial infections.

 Joint Meeting 2020 Swiss Societies for Infectious Diseases (SSI) and Hospital Hygiene (SSHH), Geneva, September 02-04 2020

  • Heinonen T, Ciarlo E, Théroude C, Le Roy D, Roger T. Trained immunity confers long-term protection against systemic listeriosis
  • Ciarlo E, Heinonen T, Théroude C, Asgari F, Le Roy D, Netea M, Roger T. Trained immunity confers broad-spectrum protection against bacterial infections
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Ciarlo E, Le Roy D, Calandra T, Garlanda C, Roger T. Trained immunity increases lung phagocytes and protects from pneumococcal pneumonia

 2021

31st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Online, July 09-12 2021

  • Schrijver IT, C. Théroude, N. Antonakos, M. Perreau, G. Pantaleo, T. Calandra, Roger T. Increase of myeloid-derived suppressor cells and reduced production of cytokines by monocytic and dendritic cells in COVID-19 patients

6th European Congress of Immunology, Virtual ECI 2021, September 01-04 2021

  • Roger T, Heinonen T, Ciarlo E, Théroude C, Schrijver IT, Pralong F, Reverté Royo N, Le Roy D. Trained immunity confers prolonged protection against systemic listeriosis

Joint annual meeting 2021 of the Swiss Societies for Infectious Diseases (SSI), Hospital Hygiene (SSHH), Tropical Medicine and Parasitology (SSTMP) and the Swiss Society of Tropical and Travel Medicine (SSTTM), Montreux, September 02-03 2021

  • Roger T, Heinonen T, Ciarlo E, Théroude C, Schrijver IT, Pralong F, Reverté Royo N, Le Roy D. Trained immunity confers prolonged protection against systemic listeriosis
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Ciarlo E, Le Roy D, Calandra T, Garlanda C, Roger T. Trained immunity increases lung antimicrobial activity of PMNs and protects from pneumococcal pneumonia

Research Day of the Department of Medicine and the Department of Laboratory Medicine and Pathology, CHUV, Lausanne, February 27 2021

  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Trained immunity increases lung phagocytes and protects from pneumococcal pneumonia.

2019

  • F. Asgari, N. Polentarutti, R. Parente, S. Davoudian, F. Pasqualini, S. Domenico, M. Stravalaci, C. Perucchini, M. Sironi, B. Marialuisa, R. Porte, S. Jaillon, A. Mantovani and C. Garlanda. Pentraxin3 plays a role in defense against Klebsiella pneumoniae infection.  PhD retreat- Milan
  • F. Asgari, N. Polentarutti, R. Parente, S. Davoudian, F. Pasqualini, S. Domenico, M. Stravalaci, C. Perucchini, M. Sironi, B. Marialuisa, R. Porte, S. Jaillon, A. Mantovani and C. Garlanda. The role of Pentraxin3 in defense against Klebsiella pneumoniae infection. 5th International Congress of translational medicine on pathogenesis and therapy of immunomediated disease- Milan
  • F. Asgari, N. Polentarutti, R. Parente, S. Davoudian, F. Pasqualini, S. Domenico, M. Stravalaci, C. Perucchini, M. Sironi, B. Marialuisa, R. Porte, S. Jaillon, A. Mantovani and C. Garlanda. Pentraxin3 plays an important role in defense against Klebsiella pneumoniae infection. Research Day-Milan. 16th International Conference on Innate Immunity- Rhodes/Greece
  • Ciarlo E, Heinonen T, Théroude C, Asgari F, Netea M, Le Roy D, Roger T. Trained immunity confers broad-spectrum protection against bacterial infections. 4th International Conference on Innate Immune Memory, New Frontiers in Innate Immune Memory, Nijmegen, The Netherlands, October 31-November 01 2019
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Trained immunity protects from pneumococcal pneumonia. 4th International Conference on Innate Immune Memory, New Frontiers in Innate Immune Memory, Nijmegen, The Netherlands, October 31-November 01 2019
  • Heinonen T, Ciarlo E, Rigoni E, Regina J, Théroude C, Le Roy D, Roger T. The sirtuins SIRT2 and SIRT3 act in concert to modulate innate immune responses.(Research Day of the Department of Medicine, CHUV, Lausanne, February 21 2019)
  • Schrijver IT, Théroude C, Calandra T, Roger T. Diagnostic Profiling of MDSCs in Sepsis. (9th joint EPFL-UNIL PhD Retreat, Les Diablerets, Switzerland, March 01-03 2019)
  • Schrijver IT, Herderschee J, Theroude C, Fenwick C, Baumgartner P, Harari A, Leijte G, Kox M, Pantaleo G, Pickkers P, Calandra T, Roger T. Myeloid-derived suppressor cells (MDSCs) in healthy subjects infused with endotoxin. (Day 2019, Lausanne, April 10 2019)
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Modulation of innate lymphoid cells (ILCs) during sepsis induced by pneumococcal infection. (Day 2019, Lausanne, April 10 2019)
  • Schrijver IT, Herderschee J, Theroude C, Fenwick C, Baumgartner P, Harari A, Leijte G, Kox M, Pantaleo G, Pickkers P, Calandra T, Roger T. Myeloid-derived suppressor cells (MDSCs) in healthy subjects infused with endotoxin. (Joint Annual Meeting 2018 of the Swiss Societies for Intensive Medicine (SSMI), Infectious Diseases (SSI), Hospital Hygiene (SSHH), Tropical Medicine and Parasitology (SSTMP) and the Swiss Society of Tropical and Travel Medicine (SSTTM), EPFL-Lausanne, September 18-20 2019)
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Innate lymphoid cells (ILCs) during S.pneumoniae pneumonia. (Joint Annual Meeting 2018 of the SSMI, SSI, SSHH, SSTMP and SSTTM, EPFL-Lausanne, September 18-20 2019)
  • Karakike, M.Roumpoutsou, N.Karampela, E. Massa, E.Antypa, K.Psaroulis, P.Chaloulis, E.Pappa, V.Kolonia, E. J. Giamarellos-Bourboulis, I. Tsangaris. A double- blind, randomized, placebo-controlled clinical study of the efficacy of intravenous clarithromycin as adjunctive treatment in patients with sepsis and respiratory and multiple organ dysfunction syndrome: the INCLASS study. 39th ISICEM conference, Brussels, Belgium, March 2019
  • Karakike, A. Alban, E.J. Giamarellos-Bourboulis, S.E. Chick. Exploring alternative trial designs for pragmatic clinical studies: A Bayesian decision-theoretic model applied on a real ongoing one-stage trial. 39th ISICEM conference, Brussels, Belgium, March 2019
  • Renieris G., Karageorgos A., Bauer M., Sabrakos L, Papapetropoulos A, Giamarellos-Bourboulis EJ. Impact of host-derived hydrogen sulphide production on susceptibility to Pseudomonas aeruginosa infection: evidence for altered quorum system gene expression. 29th ECCMID (April 2019, Amsterdam, Netherlands). [click to see poster]
  • Chloé Albert Vega*, Brengel-Pesce K, Lopez J, Desormeaux P, Pachot A, Rimmelé T, Venet F, Leray V, Monneret G, Delwarde B, Mallet F, Trouillet-Assant S. Deciphering heterogeneity in Septic Shock Patients using Immune Functional Assays: a proof of concept study. 29th ECCMID (April 2019, Amsterdam, Netherlands). [click to see poster]
  • Chloé Albert Vega: “Immune dysfunction-based stratification of septic shock patients: a proof-of-concept study”. XVIIIth congress of the European Shock Society and IXth Congress of the Int Federation of shock societies (October 2019, Crete)

2018

  • Heinonen T, Ciarlo E, Théroude C, Le Roy D, Auwerx J, Roger T. Sirtuin 5 deficiency has no major impact on innate immune responses to bacterial infections (Research Day of the Department of Medicine, CHUV, Lausanne, February 28 2018.)
  • Heinonen T, Ciarlo E, Théroude C, Le Roy D, Auwerx J, Roger T. Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections (5th European Congress of Immunology (ECI) 2018, Amsterdam, Netherlands, September 2-5 2018)
  • Ciarlo E, Heinonen T, Théroude C, Pelekanou A, Herderschee J, Le Roy D and Roger T. Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections.( Joint Annual Meeting 2018 of the Swiss Societies for Infectious Diseases (SSI), Hospital Hygiene (SSHH), Tropical Medicine and Parasitology (SSTMP) and the Swiss Society of Tropical and Travel Medicine (SSTTM), Interlaken, September 13-14 2018)
  • Nora Suzanne Wolff et al., Vendor effects on murine gut microbiota and its influence on lipopolysaccharide induced lung inflammation and Gram-negative pneumonia. (New Frontiers in Innate Immunity & Inflammation, Sept. 2018, Cluj, Romania).
  • Dina M. Tawfik et al., Immune profiling of host response biomarkers through transcriptomic analysis using FilmArray system. ISICEM conference, Brussels, Belgium. March2018
  • Eleni Karakike, Iraklis Tsangaris, Athina Savva, ChrisFna Routsi, Konstantinos Leventogiannis, Maria Tsilika, Vassiliki Apollonatou, Ioannis Tomos, Jean-Louis Vincent, Evangelos J Giamarellos-Bourboulis. Can early changes in SOFA score predict early outcome? An analysis of two cohorts. 38th ISICEM conference, Brussels, Belgium. March 2018

2017

  • Regulation of the expression of IL-1R8, a regulatory member of the Interleukin-1 receptor family. Supino D, Molgora M, Ponzetta A, Barbagallo M, Magrini E, Berthenet K, Gianni F, Asgari F,Perucchini Ch, Jaillon S, Mantovani A and Garlanda C. (May 2017, Bari, Italy, SIICA congress)
  • The long pentraxin PTX3 has a non-redundant role in the control of Streptococcus pneumoniaeinvasive infections. Porte R, Davoudian S, Asgari F, Parente R, Sironi M, Pasqualini F, Barbagallo M, Silva-Gomes R, Van der Poll T, Garlanda C, Bottazzi B and  Mantovani A. (Sep 2017, ISF 11th annual symposium, Paris, France)
  • Schrijver I, Roger T, Calandra T. Dynamic profiling of MDSCs in sepsis. 7thJoint EPFL-UNIL PhD Retreat. (March 2017, Les Diablerets, Switzerland)
  • Théroude C, Calandra T, Roger T. Innate lymphoid cells in sepsis. 7thJoint EPFL-UNIL PhD Retreat.(March 2017, Les Diablerets, Switzerland)
  • BACH1 (BTB and CNC homology 1), the oncogenic regulator enhances migration of HT-29 colon cancer cells. Sadaf Davoudian, Neda Shajari, Shima Salehi, Behzad Mansoori, Ali Mohammadi, Behzad Baradaran. (May 2017, Bari, Italy, SIICA congress)
  • The long pentraxin PTX3 has a non-redundant role in the control of Streptococcus pneumoniae invasive infections. Porte Rémi, Davoudian Sadaf, Asgari Fatemeh, Parente Raffaella, Sironi Marina,2 Pasqualini Fabio, Barbagallo Maria Luisa, Silva-Gomes Rita, Van der Poll Tom, Garlanda Cecilia, Bottazzi Barbara and  Mantovani Alberto. (Sep 2017, ISF 11thannual symposium, Paris, France)
  • PTX3 and factor H functionally cooperate in promoting phagocytosis of Aspergillus fumigatus. Parente R, Petroni F., Porte R. , Sadaf Davoudian, Sironi M., Valentino S.1, Bottazzi B., Mantovani A., Inforzato A. (May 2017, Bari, Italy, SIICA congress)

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